Enzon Announces Two Oral Presentations at the Symposium of Drug Delivery Systems in Nanjing, China
The first oral presentation, titled "PEG-based Prodrugs Improve the Anticancer Activity of Small Molecule Cytotoxics," will be given by
Dr. Zhao's presentation will cover the use of Enzon's innovative, releasable Customized Linker Technology® as a means of improving the therapeutic activity of approved small molecule cytotoxic agents. The presentation will include data demonstrating the ability of Enzon's releasable PEG linkers to increase solubility, provide extended exposure of the released cytotoxic, reduce unwanted toxicities, improve tumor accumulation of the cytotoxic agent and, most remarkably, dramatically enhance antitumor activity in animal models compared to non-PEGylated agents. Dr. Zhao will also highlight the use of PEGylation with anti-cancer agents in the clinic, including the Enzon-developed molecule PEG-SN38, which is currently undergoing clinical evaluation in patients with advanced colorectal, breast, or pediatric cancers. Development and commercialization rights to PEG-SN38 in
The second oral presentation, titled "The Proven Therapeutic Utility of Permanent and Releasable PEGylation Linkers," will be given by
Dr. Conover will present an overview of Enzon's innovative, permanent and releasable Customized Linker Technology® in commercial, clinical and research applications across disease areas and therapeutic classes. Enzon has developed the industry leading PEGylation technologies utilizing both permanent and releasable Customized Linker Technology®. To date, the Company's technology and know-how have been used to develop eight marketed products with combined annual sales of over
Companies interested in partnership opportunities to gain access to Enzon's PEGylation technology can contact Enzon at email@example.com
About Enzon's Customized Linker Technology®
PEGylation has successfully been used on various pharmaceutical compounds, including enzymes, peptides and antibodies, to improve their pharmaceutical properties through the chemical attachment of polyethylene glycol (PEG) using our Customized Linker Technology. PEGylation technology employs proprietary chemical linkers designed to either release the native molecule at a controlled rate or provide permanent linkage that will maximize inherent activity of the parent molecule. In some cases, PEGylation can render a compound therapeutically effective, whereas the unmodified form had only limited clinical utility.
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