001 - Document - DOCUMENT AND ENTITY INFORMATION link:presentationLink link:definitionLink link:calculationLink 002 - Statement - CONSOLIDATED BALANCE SHEETS link:presentationLink link:definitionLink link:calculationLink 003 - Statement - CONSOLIDATED BALANCE SHEETS [Parenthetical] link:presentationLink link:definitionLink link:calculationLink 004 - Statement - CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS) link:presentationLink link:definitionLink link:calculationLink 005 - Statement - CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY link:presentationLink link:definitionLink link:calculationLink 006 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS link:presentationLink link:definitionLink link:calculationLink 007 - Disclosure - Description of Business link:presentationLink link:definitionLink link:calculationLink 008 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:definitionLink link:calculationLink 009 - Disclosure - Recently Adopted Accounting Pronouncements link:presentationLink link:definitionLink link:calculationLink 010 - Disclosure - Marketable Securities link:presentationLink link:definitionLink link:calculationLink 011 - Disclosure - Property and Equipment link:presentationLink link:definitionLink link:calculationLink 012 - Disclosure - Notes Payable link:presentationLink link:definitionLink link:calculationLink 013 - Disclosure - Accrued Expenses and Other link:presentationLink link:definitionLink link:calculationLink 014 - Disclosure - Stockholders' Equity link:presentationLink link:definitionLink link:calculationLink 015 - Disclosure - Sale of In-Process Research and Development link:presentationLink link:definitionLink link:calculationLink 016 - Disclosure - Contract Research and Development Revenue and Miscellaneous Income link:presentationLink link:definitionLink link:calculationLink 017 - Disclosure - Cash Dividend link:presentationLink link:definitionLink link:calculationLink 018 - Disclosure - Loss Per Common Share link:presentationLink link:definitionLink link:calculationLink 019 - Disclosure - Restructurings link:presentationLink link:definitionLink link:calculationLink 020 - Disclosure - Stock Options link:presentationLink link:definitionLink link:calculationLink 021 - Disclosure - Restricted Stock Awards and Restricted Stock Units (Nonvested Shares) link:presentationLink link:definitionLink link:calculationLink 022 - Disclosure - Employee Stock Purchase Plan link:presentationLink link:definitionLink link:calculationLink 023 - Disclosure - Income Taxes link:presentationLink link:definitionLink link:calculationLink 024 - Disclosure - Significant Agreements link:presentationLink link:definitionLink link:calculationLink 025 - Disclosure - Commitments and Contingent Liabilities link:presentationLink link:definitionLink link:calculationLink 026 - Disclosure - Leases link:presentationLink link:definitionLink link:calculationLink 027 - Disclosure - Retirement Plans link:presentationLink link:definitionLink link:calculationLink 028 - Disclosure - Discontinued Operations link:presentationLink link:definitionLink link:calculationLink 029 - Disclosure - Quarterly Results of Operations (Unaudited) link:presentationLink link:definitionLink link:calculationLink 030 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:definitionLink link:calculationLink 031 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:definitionLink link:calculationLink 032 - Disclosure - Marketable Securities (Tables) link:presentationLink link:definitionLink link:calculationLink 033 - Disclosure - Property and Equipment (Tables) link:presentationLink link:definitionLink link:calculationLink 034 - Disclosure - Accrued Expenses and Other (Tables) link:presentationLink link:definitionLink link:calculationLink 035 - Disclosure - Stockholders' Equity (Tables) link:presentationLink link:definitionLink link:calculationLink 036 - Disclosure - Restructurings (Tables) link:presentationLink link:definitionLink link:calculationLink 037 - Disclosure - Stock Options (Tables) link:presentationLink link:definitionLink link:calculationLink 038 - 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Disclosure - Marketable Securities (Details) link:presentationLink link:definitionLink link:calculationLink 047 - Disclosure - Marketable Securities (Details 1) link:presentationLink link:definitionLink link:calculationLink 048 - Disclosure - Marketable Securities (Details Textual) link:presentationLink link:definitionLink link:calculationLink 049 - Disclosure - Property and Equipment (Details) link:presentationLink link:definitionLink link:calculationLink 050 - Disclosure - Property and Equipment (Details Textual) link:presentationLink link:definitionLink link:calculationLink 051 - Disclosure - Notes Payable (Details Textual) link:presentationLink link:definitionLink link:calculationLink 052 - Disclosure - Accrued Expenses and Other (Details) link:presentationLink link:definitionLink link:calculationLink 053 - Disclosure - Stockholders' Equity (Details) link:presentationLink link:definitionLink link:calculationLink 054 - Disclosure - Stockholders' Equity (Details Textual) link:presentationLink link:definitionLink link:calculationLink 055 - Disclosure - Sale of In-Process Research and Development (Details Textual) link:presentationLink link:definitionLink link:calculationLink 056 - Disclosure - Contract Research and Development Revenue and Miscellaneous Income (Details Textual) link:presentationLink link:definitionLink link:calculationLink 057 - Disclosure - Cash Dividend (Details Textual) link:presentationLink link:definitionLink link:calculationLink 058 - Disclosure - Loss Per Common Share (Details Textual) link:presentationLink link:definitionLink link:calculationLink 059 - Disclosure - Restructurings (Details) link:presentationLink link:definitionLink link:calculationLink 060 - Disclosure - Restructurings (Details 1) link:presentationLink link:definitionLink link:calculationLink 061 - Disclosure - Restructurings (Details Textual) link:presentationLink link:definitionLink link:calculationLink 062 - Disclosure - Stock Options (Details) link:presentationLink link:definitionLink link:calculationLink 063 - Disclosure - Stock Options (Details 1) link:presentationLink link:definitionLink link:calculationLink 064 - Disclosure - Stock Options (Details 2) link:presentationLink link:definitionLink link:calculationLink 065 - Disclosure - Stock Options (Details Textual) link:presentationLink link:definitionLink link:calculationLink 066 - Disclosure - Restricted Stock Awards and Restricted Stock Units (Nonvested Shares) (Details) link:presentationLink link:definitionLink link:calculationLink 067 - Disclosure - Restricted Stock Awards and Restricted Stock Units (Nonvested Shares) (Details 1) link:presentationLink link:definitionLink link:calculationLink 068 - Disclosure - Restricted Stock Awards and Restricted Stock Units (Nonvested Shares) (Details Textual) link:presentationLink link:definitionLink link:calculationLink 069 - Disclosure - Employee Stock Purchase Plan (Details) link:presentationLink link:definitionLink link:calculationLink 070 - Disclosure - Employee Stock Purchase Plan (Details 1) link:presentationLink link:definitionLink link:calculationLink 071 - Disclosure - Employee Stock Purchase Plan (Details Textual) link:presentationLink link:definitionLink link:calculationLink 072 - Disclosure - Income Taxes (Details) link:presentationLink link:definitionLink link:calculationLink 073 - Disclosure - Income Taxes (Details 1) link:presentationLink link:definitionLink link:calculationLink 074 - Disclosure - Income Taxes (Details 2) link:presentationLink link:definitionLink link:calculationLink 075 - Disclosure - Income Taxes (Details Textual) link:presentationLink link:definitionLink link:calculationLink 076 - Disclosure - Significant Agreements (Details Textual) link:presentationLink link:definitionLink link:calculationLink 077 - Disclosure - Leases (Details) link:presentationLink link:definitionLink link:calculationLink 078 - Disclosure - Leases (Details Textual) link:presentationLink link:definitionLink link:calculationLink 079 - Disclosure - Retirement Plans (Details Textual) link:presentationLink link:definitionLink link:calculationLink 080 - Disclosure - Discontinued Operations (Details) link:presentationLink link:definitionLink link:calculationLink 081 - Disclosure - Discontinued Operations (Details Textual) link:presentationLink link:definitionLink link:calculationLink 082 - Disclosure - Quarterly Results of Operations (Unaudited) (Details) link:presentationLink link:definitionLink link:calculationLink 083 - Disclosure - Quarterly Results of Operations (Unaudited) (Details Textual) link:presentationLink link:definitionLink link:calculationLink