UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(AMENDMENT NO. _____3____)*
Enzon, Inc.                        
______________________________________________________________________________
(Name of Issuer)
Common
______________________________________________________________________________
(Title of Class of Securities)
293904108
____________________________
(CUSIP Number)

Check the following box if a fee is being paid with this statement 
___.  (A fee is not required only if the filing person:  (1) has a 
previous statement on file reporting beneficial ownership of more 
than five percent of the class of securities described in Item 1; 
and (2) has filed no amendment subsequent thereto reporting 
beneficial ownership of five percent or less of such class.) (See 
Rule 13d-7).

*The remainder of this cover page shall be filled out for a 
reporting person's initial filing on this form with respect to the 
subject class of securities, and for any subsequent amendment 
containing information which would alter the disclosures provided 
in a prior cover page.

The information required in the remainder of this cover page shall 
not be deemed to be "filed" for the purpose of Section 18 of the 
Securities Exchange Act of 1934 ("Act") or otherwise subject to 
the liabilities of that section of the Act but shall be subject to 
all other provisions of the Act (however, see the Notes).

Page 1 of 3 pages
CUSIP NO. 293904108                
---------
13G
______________________________________________________________________________
1   NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

State of Wisconsin Investment Board
39-6006423        
______________________________________________________________________________
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP *
(a)_____
Not Applicable                             (b)_____
______________________________________________________________________________
3   SEC USE ONLY

______________________________________________________________________________
4   CITIZENSHIP OR PLACE OF ORGANIZATION

Madison, Wisconsin
______________________________________________________________________________
5   SOLE VOTING POWER
NUMBER OF                           2,271,000
SHARES        _____________________________________________________________
BENEFICIALLY     6   SHARED VOTING POWER
OWNED BY                            Not Applicable
EACH         _____________________________________________________________
REPORTING      7   SOLE DISPOSITIVE POWER
PERSON                             2,271,000
WITH         _____________________________________________________________
8   SHARED DISPOSITIVE POWER
Not Applicable
______________________________________________________________________________
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

2,271,000
______________________________________________________________________________
10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES  CERTAIN 
SHARES *
Not Applicable                                
______________________________________________________________________________
11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9                

9.08%
______________________________________________________________________________
12  TYPE OF REPORTING PERSON *

EP (Public Pension Fund)
______________________________________________________________________________

* SEE INSTRUCTION BEFORE FILLING OUT!

Page 2 of 3 pages

ITEM 1.  ISSUER
(a)  Enzon, Inc.                                 
(b)  40 Kingsbridge Road        
Piscata Way, NJ. 08854
ITEM 2.  PERSON FILING
(a)  State of Wisconsin Investment Board        
(b)  P.O. Box 7842
Madison, WI 53707
(c)  Wisconsin State Agency
(d)  See cover page
(e)  See cover page

ITEM 3.  THIS STATEMENT IS FILED PURSUANT TO 13D-1(B) OR 13D-2(B) AND THE STATE 
OF WISCONSIN INVESTMENT BOARD IS A GOVERNMENT AGENCY WHICH MANAGES PUBLIC
PENSION FUNDS SUBJECT TO PROVISIONS COMPARABLE TO ERISA.

ITEM 4.  OWNERSHIP
(a)  See Row 9 on Page 2
(b)  See Row 11 on Page 2
(c)  The State of Wisconsin Investment Board retains sole voting and 
dispositive power for all shares.

ITEM 5.  IF THIS STATEMENT IS BEING FILED TO REPORT THE FACT THAT AS OF THE DATE
HEREOF THE REPORTING PERSON HAS CEASED TO BE THE BENEFICIAL OWNER OF MORE THAN
FIVE PERCENT OF THE CLASS OF SECURITIES, CHECK THE FOLLOWING ____.

ITEM 6.  NOT APPLICABLE

ITEM 7.  NOT APPLICABLE

ITEM 8.  NOT APPLICABLE

ITEM 9.  NOT APPLICABLE

ITEM 10. CERTIFICATION

By signing below I certify that, to the best of my knowledge and belief,
the securities referred to above were acquired in the ordinary course of
business and were not acquired for the purpose of and do not have the effect of 
changing or influencing the control of the issuer of such securities and were
not acquired in connection with or as a participant in any transaction having
such purposes or effect.

SIGNATURE

After reasonable inquiry to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

February 13, 1995
___________________________
Date

George Natzke
___________________________
Signature

George Natzke, Administrator
___________________________
Name/Title

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