THOMAS F. MCINERNEY
                                 (212) 415-9215

                                                          December 7, 1998


Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, D.C.  20549

Attn:    Filing Desk

                  Re: Enzon, Inc.- Current Report on Form 8-K

Ladies and Gentlemen:

     On behalf of our client Enzon,  Inc. (the  "Company"),  we are transmitting
electronically  the Company's  Current Report on Form 8-K (the "Form 8-K") dated
November 20, 1998.

     Please note that the Form 8-K filed herewith contains a conformed signature
and that an original, manual signature will be retained in the Company's records
for five (5) years.

                                                          Very truly yours,



                                                          /s/THOMAS F. MCINERNEY
                                                          Thomas F. McInerney

cc: Kenneth J. Zuerblis





                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT


Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported) November 20, 1998

                                   ENZON, INC.
             (Exact name of registrant as specified in its charter)


         Delaware                       0-12957                     22-2372868
(State or other jurisdiction          (Commission                 (IRS EMPLOYER
      or incorporation)               File Number)               Identification)
                                


20 Kingsbridge Road, Piscataway, New Jersey                           08854
(Address of principal executive offices)                            (Zip Code)


Registrant's telephone number, including area code                (732) 980-4500


- --------------------------------------------------------------------------------
          (Former name or former address, if changed since last report)





Item 5.  Other Events

     Schering-Plough  Corporation  has advanced  PEG-INTRON  A(R), a long-acting
dose  formulation  of  Schering-Plough's  INTRON(R)  A, into Phase III  clinical
trials for chronic myelogenous leukemia.

     PEG-INTRON A is in Phase III clinical  trials for hepatitis C and malignant
melanoma and is in early phase clinical  trials for solid tumors,  as well as in
combination with REBETOL (R) for hepatitis C.

     Except for the historical information herein, the matters discussed in this
Form 8-K include  forward-looking  statements that may involve a number of risks
and uncertainties.  Actual results may vary significantly based upon a number of
factors  which are described in the  Company's  Form 10-Ks,  Form 10-Qs and Form
8-Ks on file with the SEC, including without limitation,  risks in obtaining and
maintaining  regulatory approval for expanded indications,  market acceptance of
an continuing demand for Enzon's products and the impact of competitive products
and pricing.





                                   SIGNATURES

     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.


Dated: December 7, 1998

                                     ENZON, INC. 
                                     (Registrant)

                                     By:  /s/ Kenneth J. Zuerblis
                                          --------------------------------------
                                          Kenneth J. Zuerblis
                                          Vice President, Finance
                                          and Chief Financial Officer (Principal
                                          Financial Officer and Principal
                                          Accounting Officer)