ENZON PHARMACEUTICALS, INC.

March 29, 2006



VIA Facsimile and EDGAR

Division of Corporation Finance
Securities and Exchange Commission
100 F Street, NE
Washington, D.C. 20549
Attention:        John L. Krug
                  Jeffrey Riedler

Re:      Enzon Pharmaceuticals, Inc.
         Preliminary Proxy Statement filed March 22, 2006
         File No. 000-12957

Gentlemen:

     In connection with our response to the letter dated March 28, 2006 from the
     Staff of the Commission, the Staff providing certain comments regarding the
     Schedule 14A Preliminary  Proxy Statement (the "Proxy  Statement") of Enzon
     Pharmaceuticals,  Inc. (the "Company") filed on March 22, 2006, the Company
     acknowledges that:

     o    the  Company is  responsible  for the  adequacy  and  accuracy  of the
          disclosure in the filing;

     o    staff  comments or changes to disclosure in response to staff comments
          do not foreclose the Commission from taking any action with respect to
          the filing; and

     o    the  Company  may  not  assert  staff  comments  as a  defense  in any
          proceeding initiated by the Commission or any person under the federal
          securities laws of the United States.

                                    Very truly yours,




                                    By: /s/ LAWRENCE R. MILLER
                                    Name:  Lawrence R. Miller
                                    Title:  Vice President and General Counsel

cc:      Kevin T. Collins, Esq.


[GRAPHIC OMITTED][GRAPHIC OMITTED]
HELLER EHRMAN LLP
                                                                  March 28, 2006





March 28, 2006                                               Kevin T. Collins
                                                                  Shareholder
Via Facsimile and EDGAR                        Kevin.Collins@hellerehrman.com
                                                       Direct +1.212.847.8742
                                                   Direct Fax +1.212.703.8942
                                                         Main +1.212.832.8300
                                                          Fax +1.212.763.7600



Division of Corporation Finance
Securities and Exchange Commission
100 F Street, NE
Washington, D.C. 20549
Attention:        John L. Krug
                  Jeffrey Riedler
Re:      Enzon Pharmaceuticals, Inc.
         Preliminary Proxy Statement filed March 22, 2006
         File No. 000-12957

Gentlemen:

     By letter dated March 28, 2006 from the Staff of the Commission,  the Staff
provided certain comments regarding the Schedule 14A Preliminary Proxy Statement
(the "Proxy Statement") of Enzon Pharmaceuticals,  Inc. (the "Company") filed on
March 22,  2006.  On behalf of the  Company,  we are  responding  to the comment
letter in the following  numbered  paragraph which  corresponds to the paragraph
number in the comment letter. To respond to the comment letter, the Company will
include the change described below when it files its Definitive Proxy Statement.

Proposal 3: Approval of increase in number of authorized shares of common stock

     Please  expand  the   discussion  to  state  whether  you  have  any  plan,
commitment,  arrangement,  understanding  or agreement,  either oral or written,
regarding the issuance of common stock  subsequent to the increase in the number
of authorized shares.

     Response:   The  Company  does  not  have  any  current  plan,  commitment,
arrangement,  understanding or agreement,  either oral or written, regarding the
issuance of common stock  subsequent to the increase in the number of authorized
shares. The fourth paragraph of Proposal 3 will be revised to add the underlined
disclosure (last sentence) below:

     "The purpose of the proposed  amendment is to allow us to have a sufficient
number of shares of authorized and unissued  common stock which can be issued in
connection  with such corporate  purposes as may be considered  advisable by the
Board.  Having such  shares  available  for  issuance in the future will give us
greater flexibility and will allow such shares to be issued as determined by the
Board  without the expense and delay of a special  stockholders'  meeting.  Such
stock could be used, for example,  for  acquisitions,  for stock splits or stock
dividends,  for  our  employee  benefit  plans,  or in  connection  with  equity
or convertible debt financings.  We do not have any currently existing
plan,  commitment,  arrangement,  understanding  or  agreement,  either  oral or
written,  regarding  the issuance of common stock  subsequent to the increase in
the number of authorized shares."

     A  statement  of  the  Company  acknowledging  that:  (i)  the  Company  is
responsible for the adequacy and accuracy of the disclosure in the filing;  (ii)
staff  comments or changes to  disclosure  in response to staff  comments do not
foreclose the Commission from taking any action with respect to the filing;  and
(iii) the Company may not assert staff  comments as a defense in any  proceeding
initiated by the Commission or any person under the federal  securities  laws of
the United States is enclosed.

     Please  contact me at (212)  847-8742  or Molly  Gardner of this  office at
(212) 847-8757 if you have any questions regarding the foregoing.

                                  Very truly yours,


                                  /s/ KEVIN T. COLLINS
                                  Kevin T. Collins



cc:      Lawrence R. Miller, Esq.


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