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ENZON PHARMACEUTICALS, INC. c/o Continental Proxy Services 1 State Street, New York NY 10004 You May Vote Your Proxy When You View The Material On The Internet. You Will Be Asked To Follow The Prompts To Vote Your Shares. Enzon Pharmaceuticals, Inc. 20 Commerce Drive, Suite 135 Cranford, New Jersey 07016 NOTICE OF ANNUAL MEETING OF STOCKHOLDERS to be held on Thursday, August 22, 2019 *Stockholders are cordially invited to attend the 2019 Annual Meeting and vote in person. Dear Stockholder, The 2019 Annual Meeting of Stockholders (the “2019 Annual Meeting”) of Enzon Pharmaceuticals, Inc. (the “Company”) will be held at Club 101 on the Main Floor at 101 Park Avenue, New York, New York 10178 on Thursday, August 22, 2019 at 11:00 a.m., local time. Proposals to be considered at the 2019 Annual Meeting: (1) to elect three (3) directors, each for a one-year term expiring at the Company’s next annual meeting of stockholders and until such director’s successor is elected and qualified; (2) to ratify the appointment of EisnerAmper LLP as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2019; (3) to approve, on an advisory basis, the compensation of the Company’s named executive officers; and (4) to transact such other matters as may properly come before the 2019 Annual Meeting or any adjournment or postponement thereof. The Company’s Board of Directors has proposed and recommends that stockholders vote “FOR” each of the nominees to the Board of Directors listed in Proposal No. 1 and “FOR” Proposals Nos. 2 and 3. Your electronic vote authorizes the named proxies to vote your shares in the same manner as if you marked, signed, dated, and returned the proxy card. Vote Your Proxy on the Internet: Go to http://www.cstproxyvote.com Have your notice available when you access the above website. Follow the prompts to vote your shares. The Proxy Statement and our Annual Report on Form 10-K for the fiscal year ended December 31, 2018 are available online at: CONTROL NUMBER The Proxy Materials are available for review at: http://www.cstproxy.com/enzon/2019

ENZON PHARMACEUTICALS, INC. 20 Commerce Drive, Suite 135 Cranford, New Jersey 07016 Important Notice Regarding the Availability of Proxy Materials For the 2019 Stockholder Meeting to Be Held On Thursday , August 22, 2019 This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. We encourage you to access and review all of the important information contained in the proxy materials before voting. If you would like to receive a paper or e mail copy of these documents, you must request one. There is no charge for such documents to be mailed to you. Please make your request for a copy as instructed below on or before July 30, 2019 to facilitate a timely delivery. The following Proxy Materials for the 2019 Annual Meeting are available to you to review at: http://www.cstproxy.com/enzon/2019 - the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2018; - the Company’s Proxy Statement for the 2019 Annual Meeting; - the Proxy Card for the 2019 Annual Meeting; and – any amendments to the foregoing materials that are required to be furnished to stockholders. You may contact the Company at (732) 980-4500 or through an e-mail request to investor@enzon.com for directions to the 2019 Annual Meeting. ACCESSING YOUR PROXY MATERIALS ONLINE Have this notice available when you request a paper copy of the proxy materials or to vote your proxy electronically. You must reference your company ID., proxy number, and account number. REQUESTING A PAPER COPY OF THE PROXY MATERIALS By telephone please call 1-888-221-0691, or By logging on to http://www.cstproxy.com/enzon/2019 or By email at: proxy@continentalstock.com Please include the company name and your control number in the subject line.