SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C.  20549

                                 SCHEDULE 13G
                                (Rule 13d-102)


             INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
           TO RULES 13d-1(b)(c), AND (d) AND AMENDMENTS THERETO FILED
                           PURSUANT TO RULE 13d-2(b)


                               (Amendment No. 1)*


                           Enzon Pharmaceuticals, Inc.
             -----------------------------------------------------
                                (Name of Issuer)

                                  Common Stock
             -----------------------------------------------------
                         (Title of Class of Securities)

                                    293904108
             -----------------------------------------------------
                                 (CUSIP Number)


                               December 31, 2007
             -----------------------------------------------------
            (Date of Event Which requires Filing of this Statement)



     Check the  appropriate  box to  designate  the rule  pursuant to which this
Schedule is filed:

          [X]  Rule 13d-1(b)

          [_]  Rule 13d-(c)

          [_]  Rule 13d-1(d)


- ----------
*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                                Page 1 of 10 Pages




CUSIP No. 293904108           Schedule 13G             Page 2 of 10 Pages


________________________________________________________________________________
1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     Iridian Asset Management LLC

________________________________________________________________________________
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [_]
                                                                 (b)  [X]

________________________________________________________________________________
3.   SEC USE ONLY



________________________________________________________________________________
4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware

________________________________________________________________________________
  NUMBER OF    5.   SOLE VOTING POWER

   SHARES           0
               _________________________________________________________________
BENEFICIALLY   6.   SHARED VOTING POWER

  OWNED BY          6,404,249
               _________________________________________________________________
    EACH       7.   SOLE DISPOSITIVE POWER

  REPORTING         0
               _________________________________________________________________
   PERSON      8.   SHARED DISPOSITIVE POWER

    WITH            6,404,249
________________________________________________________________________________
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     6,404,249

________________________________________________________________________________
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          [_]

________________________________________________________________________________
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     14.5%

________________________________________________________________________________
12.  TYPE OF REPORTING PERSON*

     IA

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!





CUSIP No. 293904108           Schedule 13G             Page 3 of 10 Pages


________________________________________________________________________________
1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     The Governor and Company of the Bank of Ireland

________________________________________________________________________________
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [_]
                                                                 (b)  [X]

________________________________________________________________________________
3.   SEC USE ONLY



________________________________________________________________________________
4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     Republic of Ireland

________________________________________________________________________________
  NUMBER OF    5.   SOLE VOTING POWER

   SHARES           0
               _________________________________________________________________
BENEFICIALLY   6.   SHARED VOTING POWER

  OWNED BY          6,404,249
               _________________________________________________________________
    EACH       7.   SOLE DISPOSITIVE POWER

  REPORTING         0
               _________________________________________________________________
   PERSON      8.   SHARED DISPOSITIVE POWER

    WITH            6,404,249
________________________________________________________________________________
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     6,404,249

________________________________________________________________________________
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          [_]

________________________________________________________________________________
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     14.5%

________________________________________________________________________________
12.  TYPE OF REPORTING PERSON*

     CO

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!



CUSIP No. 521863308           Schedule 13G             Page 4 of 10 Pages


________________________________________________________________________________
1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     BIAM Holdings

________________________________________________________________________________
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [_]
                                                                 (b)  [X]

________________________________________________________________________________
3.   SEC USE ONLY



________________________________________________________________________________
4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     Republic of Ireland

________________________________________________________________________________
  NUMBER OF    5.   SOLE VOTING POWER

   SHARES           0
               _________________________________________________________________
BENEFICIALLY   6.   SHARED VOTING POWER

  OWNED BY          6,404,249
               _________________________________________________________________
    EACH       7.   SOLE DISPOSITIVE POWER

  REPORTING         0
               _________________________________________________________________
   PERSON      8.   SHARED DISPOSITIVE POWER

    WITH            6,404,249
________________________________________________________________________________
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     6,404,249

________________________________________________________________________________
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          [_]

________________________________________________________________________________
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     14.5%

________________________________________________________________________________
12.  TYPE OF REPORTING PERSON*

     CO

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!




CUSIP No. 293904108           Schedule 13G             Page 5 of 10 Pages


________________________________________________________________________________
1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     BancIreland (US) Holdings, Inc.

________________________________________________________________________________
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [_]
                                                                 (b)  [X]

________________________________________________________________________________
3.   SEC USE ONLY



________________________________________________________________________________
4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     New Hampshire

________________________________________________________________________________
  NUMBER OF    5.   SOLE VOTING POWER

   SHARES           0
               _________________________________________________________________
BENEFICIALLY   6.   SHARED VOTING POWER

  OWNED BY          6,404,249
               _________________________________________________________________
    EACH       7.   SOLE DISPOSITIVE POWER

  REPORTING         0
               _________________________________________________________________
   PERSON      8.   SHARED DISPOSITIVE POWER

    WITH            6,404,249
________________________________________________________________________________
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     6,404,249

________________________________________________________________________________
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          [_]

________________________________________________________________________________
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     14.5%

________________________________________________________________________________
12.  TYPE OF REPORTING PERSON*

     CO

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!




CUSIP No. 293904108           Schedule 13G             Page 6 of 10 Pages


________________________________________________________________________________
1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     BIAM (US) Inc.

________________________________________________________________________________
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [_]
                                                                 (b)  [X]

________________________________________________________________________________
3.   SEC USE ONLY



________________________________________________________________________________
4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware

________________________________________________________________________________
  NUMBER OF    5.   SOLE VOTING POWER

   SHARES           0
               _________________________________________________________________
BENEFICIALLY   6.   SHARED VOTING POWER

  OWNED BY          6,404,249
               _________________________________________________________________
    EACH       7.   SOLE DISPOSITIVE POWER

  REPORTING         0
               _________________________________________________________________
   PERSON      8.   SHARED DISPOSITIVE POWER

    WITH            6,404,249
________________________________________________________________________________
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     6,404,249

________________________________________________________________________________
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          [_]

________________________________________________________________________________
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     14.5%

________________________________________________________________________________
12.  TYPE OF REPORTING PERSON*

     CO

________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!



CUSIP No. 293904108             SCHEDULE 13G              Page 7 of 10 Pages

This Amendment  amends in its entirety the Schedule 13G previously filed for the
month ended December 31, 2006.

________________________________________________________________________________
Item 1(a).  Name of Issuer:

            Enzon Pharmaceuticals, Inc.

________________________________________________________________________________
Item 1(b).  Address of Issuer's Principal Executive Offices:

            685 Route 202/206
            Bridgewater, NJ 08807

________________________________________________________________________________
Item 2.

(a)  Name of Person Filing.

This  Statement is being filed by and on behalf of Iridian Asset  Management LLC
("Iridian"),  The  Governor  and  Company of the Bank of  Ireland  (the "Bank of
Ireland"),   BIAM Holdings  ("Holdings"),   BancIreland (US) Holdings, Inc.
("BancIreland"), and BIAM (US) Inc. (collectively, the "Reporting Persons").


(b) Address of Principal Business Office:

The principal  business address of Iridian is 276 Post Road West,  Westport,  CT
06880-4704.

The principal  business  address of Bank of Ireland and Holdings is Head Office,
Lower Baggot Street, Dublin 2, Ireland.

The principal business address of BancIreland and BIAM (US) Inc. is Liberty Park
#15, 282 Route 101, Amherst, NH 03110.

(c)  Citizenship or Place of  Organization:

Iridian is a limited liability company. Bank of Ireland and Holdings are Ireland
corporations.  BancIreland is a New Hampshire  corporation.  BIAM (US) Inc. is a
Delaware corporation.

d) Title of Class of Securities:

This Statement  relates to the shares of common stock of Enzon  Pharmaceuticals,
Inc.

(e)  CUSIP Number: The CUSIP number is 293904108.



CUSIP No. 293904108            SCHEDULE 13G              Page 8 of 10 Pages

_______________________________________________________________________________
Item 3. If This  Statement is Filed  Pursuant to Rule  13d-1(b),  or 13d-2(b) or
(c), Check Whether the Person Filing is a:

     (a)  [_]  Broker or dealer registered under Section 15 of the Exchange Act.

     (b)  [_]  Bank as defined in Section 3(a)(6) of the Exchange Act.

     (c)  [_]  Insurance  company as defined in Section 3(a)(19) of the Exchange
               Act.

     (d)  [_]  Investment  company  registered under Section 8 of the Investment
               Company Act.

     (e)  [X]  An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E);

     (f)  [_]  An employee  benefit plan or endowment  fund in  accordance  with
               Rule 13d-1(b)(1)(ii)(F);

     (g)  [X]  A parent  holding  company or control  person in accordance  with
               Rule 13d-1(b)(1)(ii)(G);

     (h)  [_]  A savings  association  as defined in Section 3(b) of the Federal
               Deposit Insurance Act;

     (i)  [_]  A church  plan that is  excluded  from the  definition  of an
               investment  company  under  Section  3(c)(14)  of the  Investment
               Company Act;

     (j)  [_]  Group, in accordance with Rule 13d-1(b)(1)(ii)(J).


If this statement is filed pursuant to Rule 13d-1(c), check this box. [_]

_______________________________________________________________________________
Item 4.     Ownership.

(a) and (b). Amount Beneficially Owned and Percent of Class:

As of the date of this Statement,  the Reporting Persons  beneficially  owned in
the aggregate  6,404,249  shares of Common Stock which equates to  approximately
14.5% of the outstanding  shares (the percentage of shares of Common Stock owned
being based upon  44,170,815  shares of Common Stock  outstanding at October 31,
2007 as set forth in the Issuer's  Quarterly Report on Form 10-Q for the quarter
ended September 30, 2007).


Iridian has direct  beneficial  ownership  of the shares of Common  Stock in the
accounts  for which it serves as the  investment  adviser  under its  investment
management agreements.


BIAM (US) Inc., as the controlling  member of Iridian,  may be deemed to possess
beneficial  ownership  of the  shares  of  Common  Stock  beneficially  owned by
Iridian. BancIreland, as the sole shareholder of BIAM (US) Inc. may be deemed to
possess beneficial ownership of the shares of Common Stock beneficially owned by
BIAM (US) Inc. Holdings,  as the sole shareholder of BancIreland,  may be deemed
to possess beneficial ownership of the shares of Common Stock beneficially owned
by BancIreland.  Bank of Ireland,  as the sole  shareholder of Holdings,  may be
deemed  to  possess   beneficial   ownership  of  the  shares  of  Common  Stock
beneficially owned by Holdings.

As used herein,  "beneficial  ownership" has the meaning set forth in Rule 13d-3
under the Securities Exchange Act of 1934, as amended.



CUSIP No. 293904108             SCHEDULE 13G              Page 9 of 10 Pages


(c) Power to vote or dispose.

Iridian has the direct power to vote or direct the vote, and the direct power to
dispose or direct the disposition, of 6,404,249 shares of Common Stock.


________________________________________________________________________________
Item 5.  Ownership of Five Percent or Less of a Class.

If this  statement  is being filed to report the fact that as of the date hereof
the  reporting  person has ceased to be the  beneficial  owner of more than five
percent of the class of securities, check the following: ____

Not Applicable.

________________________________________________________________________________
Item 6.  Ownership of More Than Five Percent on Behalf of Another Person.

Not Applicable.

________________________________________________________________________________
Item 7.  Identification and Classification of the Subsidiary Which Acquired the
         Security Being Reported on by the Parent Holding Company.

The item 3 classification of each Reporting Person is as follows:

Iridian Asset  Management LLC is an investment  adviser in accordance  with Rule
13d-1(b)(1)(ii)(E).

The Governor and Company of the Bank of Ireland is a parent  holding  company or
control person in accordance with Rule 13d-1(b)(1)(ii)(G).

BIAM Holdings  is a parent  holding  company or control person in accordance
with Rule 13d-1(b)(1)(ii)(G).

BancIreland (US) Holdings, Inc. is a parent holding company or control person
in accordance with Rule 13d-1(b)(1)(ii)(G).

BIAM (US) Inc. is a parent holding  company or control person in accordance with
Rule 13d-1(b)(1)(ii)(G).

________________________________________________________________________________
Item 8.  Identification and Classification of Members of the Group.

Not Applicable

________________________________________________________________________________
Item 9.  Notice of Dissolution of Group.

Not Applicable.

________________________________________________________________________________
Item 10.  Certifications.

By  signing  below the  undersigned  certifies  that,  to the best of its or his
knowledge  and belief,  the  securities  referred to above were acquired and are
held in the  ordinary  course of business and were not acquired and are not held
for the  purpose of and do not have the effect of changing  or  influencing  the
control of the issuer of the  securities  and were not acquired and are not held
in connection with or as a participant in any transaction having such purpose or
effect.



CUSIP No. 293904108             SCHEDULE 13-G              Page 10 of 10 Pages


                                   SIGNATURE.


After reasonable  inquiry and to the best of its or his knowledge and belief, we
certify that the information  set forth in this statement is true, complete and
correct.

Date: February 4, 2008



                              IRIDIAN ASSET MANAGEMENT LLC

                              By: /s/    Jeffrey M. Elliott
                                   ----------------------------------
                                       Jeffrey M. Elliott
                                       Executive Vice President


                              THE GOVERNOR AND COMPANY OF THE BANK OF IRELAND

                             By:   /s/   John Clifford
                                   ----------------------------------
                                        John Clifford
                                        Group Secretary


                              BIAM HOLDINGS

                             By:   /s/   John Clifford
                                   ----------------------------------
                                        John Clifford
                                        Group Secretary


                              BANCIRELAND (US) HOLDINGS, INC.

                              By:  /s/   Jeffrey M. Elliott
                                    ----------------------------------
                                        Jeffrey M. Elliott
                                        Agent

                              BIAM (US) INC.

                              By:  /s/   Jeffrey M. Elliott
                                    ----------------------------------
                                        Jeffrey M. Elliott
                                        Agent

                           LIMITED POWER OF ATTORNEY

BancIreland (US) Holdings, Inc. (the "Grantor"),  having its principal office at
282 Route 101, Liberty Park #15, Amherst,  NH 03031 is the sole owner of Iridian
Asset Management LLC (the "Adviser"),  an investment adviser registered with the
United States Securities and Exchange Commission (the "SEC").

Grantor appoints each of Jeffrey M. Elliott,  Executive Vice President and Chief
Operating Officer,  and Lane S. Bucklan,  General Counsel (each, the "Agent") of
Iridian Asset  Management  LLC as its true and lawful  attorney-in-fact  for the
following specific and limited purposes only:

To exercise or perform any act, power, duty, right or obligation whatsoever that
Grantor now has, or may subsequently  acquire the legal right, power or capacity
to  exercise  or  perform,  in  connection  with,  arising  from or  relating to
Adviser's  obligation  to make filings with the SEC under  Sections 13 and 16 of
the Securities  Exchange Act of 1934, as amended,  and the rules and regulations
promulgated thereunder, including, but not limited to, the authority to prepare,
sign,  and file all such  forms,  schedules,  or other  documents  which  may be
necessary to complete such filings.

Grantor gives and grants each Agent  individually full power and authority to do
and perform all and every act and thing  whatsoever  necessary to be done in and
about the  specific  and  limited  premises  set forth  herein as fully,  to all
intents and purposes, as might or could be done if personally present, with full
power of substitution  and revocation,  hereby ratifying and confirming all that
said Agent shall lawfully do or cause to be done by virtue hereof.

Dated: January 15, 2008

                                       BANCIRELAND (US) HOLDINGS, Inc.

                                        By: /s/ Diane  Morrison
                                        _______________________________
                                        Diane Morrison, President

Appointment  accepted by:

/s/  Jeffrey M.  Elliott
_____________________________
Jeffrey  M.  Elliott
Executive  Vice  President  and Chief
Operating Officer

/s/ Lane S. Bucklan
__________________________________
Lane S. Bucklan
General Counsel

LIMITED POWER OF ATTORNEY BIAM (US), Inc. (the "Grantor"), having its principal office at 282 Route 101, Liberty Park #15, Amherst, NH 03031 is the sole owner of Iridian Asset Management LLC (the "Adviser"), an investment adviser registered with the United States Securities and Exchange Commission (the "SEC"). Grantor appoints each of Jeffrey M. Elliott, Executive Vice President and Chief Operating Officer, and Lane S. Bucklan, General Counsel (each, the "Agent") of Iridian Asset Management LLC as its true and lawful attorney-in-fact for the following specific and limited purposes only: To exercise or perform any act, power, duty, right or obligation whatsoever that Grantor now has, or may subsequently acquire the legal right, power or capacity to exercise or perform, in connection with, arising from or relating to Adviser's obligation to make filings with the SEC under Sections 13 and 16 of the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder, including, but not limited to, the authority to prepare, sign, and file all such forms, schedules, or other documents which may be necessary to complete such filings. Grantor gives and grants each Agent individually full power and authority to do and perform all and every act and thing whatsoever necessary to be done in and about the specific and limited premises set forth herein as fully, to all intents and purposes, as might or could be done if personally present, with full power of substitution and revocation, hereby ratifying and confirming all that said Agent shall lawfully do or cause to be done by virtue hereof. Dated: January 15, 2008 BIAM (US), Inc. By: /s/ Diane Morrison ______________________________ Diane Morrison, President Appointment accepted by: /s/ Jeffrey M. Elliott _________________________________ Jeffrey M. Elliott Executive Vice President and Chief Operating Officer /s/ Lane S. Bucklan _________________________________ Lane S. Bucklan General Counsel

                             JOINT FILING AGREEMENT

This JOINT FILING  AGREEMENT is made and entered into by and among Iridian Asset
Management LLC, The Governor and Company of the Bank of Ireland,  BIAM Holdings,
BancIreland (US) Holdings, Inc. and BIAM (US) Inc.

The parties to this  Agreement  hereby agree to prepare  jointly and file timely
(or otherwise  deliver as appropriate)  all filings on Schedule 13D and Schedule
13G (the  "Filings")  required to be filed by them  pursunat to Section 13(d) or
13(g) under the  Securities  Exchange Act of 1934,  as amended,  with respect to
their respective ownership of any securities of Enzon Pharmaceuticals, Inc. that
are  required  to be  reported  on any  Filings.  Each party to this  Agreement
further  agrees and covenants to the other parties that it will fully  cooperate
with such  other  parties  in the  preparation  and  timely  filing  (and  other
delivery) of all such Filings.

Date: February 4, 2008



                              IRIDIAN ASSET MANAGEMENT LLC

                              By: /s/    Jeffrey M. Elliott
                                   ----------------------------------
                                       Jeffrey M. Elliott
                                       Executive Vice President


                              THE GOVERNOR AND COMPANY OF THE BANK OF IRELAND

                             By:   /s/   John Clifford
                                   ----------------------------------
                                        John Clifford
                                        Group Secretary


                              BIAM HOLDINGS

                             By:   /s/   John Clifford
                                   ----------------------------------
                                        John Clifford
                                        Group Secretary


                              BANCIRELAND (US) HOLDINGS, INC.

                              By:  /s/   Jeffrey M. Elliott
                                    ----------------------------------
                                        Jeffrey M. Elliott
                                        Agent

                              BIAM (US) INC.

                              By:  /s/   Jeffrey M. Elliott
                                    ----------------------------------
                                        Jeffrey M. Elliott