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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                             ---------------------

                                   SCHEDULE TO
                                 (RULE 14D-100)
            TENDER OFFER STATEMENT UNDER SECTION 14(D)(1) OR 13(E)(1)
                     OF THE SECURITIES EXCHANGE ACT OF 1934

                                (AMENDMENT NO. 3)
                             ---------------------

                           ENZON PHARMACEUTICALS, INC.
                       (Name of Subject Company (Issuer))
                             ---------------------

                           ENZON PHARMACEUTICALS, INC.
                       (Names of Filing Persons (Issuer))
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                 4 1/2% CONVERTIBLE SUBORDINATED NOTES DUE 2008
                         (Title of Class of Securities)

                                    293904AB4
                                    293904AA6
                     (CUSIP Numbers of Class of Securities)
                             ---------------------

                                SCOTT B. WALDMAN
                           ENZON PHARMACEUTICALS, INC.
                                685 ROUTE 202/206
                          BRIDGEWATER, NEW JERSEY 08807
                                 (908) 541-8600

                                    Copy to:
                             TODD R. CHANDLER, ESQ.
                           WEIL, GOTSHAL & MANGES LLP
                                767 FIFTH AVENUE
                               NEW YORK, NY 10153
                                 (212) 310-8000
                 (Name, Address and Telephone Numbers of Person
  Authorized to Receive Notices and Communications on Behalf of Filing Persons)
                             ---------------------


                            CALCULATION OF FILING FEE
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   TRANSACTION VALUATION*                         AMOUNT OF FILING FEE
- --------------------------------------------------------------------------------
        $173,700,000                                   $18,585.90
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*    Calculated solely for purpose of determining the amount of the filing fee
     pursuant to and based upon a purchase of $180,000,000 aggregate principal
     amount of Enzon's 4 1/2% Convertible Subordinated Notes due 2008 at a
     purchase price of $965 per $1,000 principal amount. The amount of the
     filing fee, $107.00 for each $1,000,000 of value, was calculated in
     accordance with Rule 0-11 of the Securities Exchange Act of 1934, as
     amended.

[X]  Check the box if any part of the fee is offset as provided by Rule
     0-11(a)(2) and identify the filing with which the offsetting fee was
     previously paid. Identify the previous filing by registration statement
     number, or the Form or Schedule and the date of its filing.

     Amount Previously Paid:  $18,585.90    Filing Party: Enzon Pharmaceuticals,
                                                           Inc.
     Form or Registration No.:Schedule TO   Date Filed:   June 6, 2006

[_]  Check the box if the filing relates solely to preliminary communications
     made before the commencement of a tender offer.

Check the appropriate boxes below to designate any transactions to which the
statement relates:

[_]     third-party tender offer subject to Rule 14d-1.
[X]     issuer tender offer subject to Rule 13e-4.
[_]     going-private transaction subject to Rule 13e-3.
[_]     amendment to Schedule 13D under Rule 13d-2.

Check the following box if the filing is a final amendment reporting the results
of the tender offer:  [_]

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This Amendment No. 3 amends the Tender Offer Statement on Schedule TO (this "SCHEDULE TO") filed by Enzon Pharmaceuticals, Inc., a Delaware corporation ("ENZON"), on June 6, 2006, as amended by Amendment No. 1 thereto filed on June 12, 2006 and Amendment No. 2 thereto filed on June 23, 2006 relating to an offer by Enzon to purchase for cash up to $180,000,000 aggregate principal amount of its 4 1/2% Convertible Subordinated Notes due 2008 (the "NOTES") plus accrued and unpaid interest to the date of repurchase upon the terms and subject to the conditions set forth in the Offer to Purchase, dated June 6, 2006, as amended, June 23, 2006 (the "OFFER TO PURCHASE"), a copy of which is filed herewith as Exhibit (a)(1)(A), and in the related Letter of Transmittal, a copy of which is filed herewith as Exhibit (a)(1)(B) (which, together with any amendments or supplements thereto, collectively constitute the "OFFER"). The Notes were issued by Enzon pursuant to an Indenture, dated as of June 26, 2001, between Enzon and Wilmington Trust Company, as trustee. This Amendment No. 3 incorporates the press release dated July 6, 2006 that announced the completion of the Offer. ITEM 12. EXHIBITS. Item 12 of the Schedule TO is hereby amended and supplemented by adding the following: (a)(1)(F) Press Release dated July 6, 2006 2

EXHIBIT INDEX EXHIBIT NO. DOCUMENT - ----------- -------- (a)(1)(A)* Offer to Purchase, dated June 6, 2006, as amended, June 23, 2006 (a)(1)(B)* Form of Letter of Transmittal (a)(1)(C)* Form of Letter to Brokers, Dealers, Commercial Banks, Trust Companies and Other Nominees (a)(1)(D)* Form of Letter to Clients for Use by Brokers, Dealers, Commercial Banks, Trust Companies and Other Nominees (a)(1)(E)* Press Release dated June 6, 2006 (a)(1)(F)+ Press Release dated July 6, 2006 (b) Not applicable (d)(1)* Indenture, dated as of June 26, 2001, between Enzon Pharmaceuticals, Inc. and Wilmington Trust Company, as trustee (filed as Exhibit 4.1 to the Enzon's Form S-3 (No. 333-67506) on August 14, 2001 and incorporated herein by reference) (d)(2)* Descriptions of Notes (filed as pages 17 through 26 of Enzon's Form S-3 (No.333-67506) on August 14, 2001 and incorporated herein by reference) (g) Not applicable (h) Not applicable - -------------------------------- + Filed herewith * Previously filed.

SIGNATURE After due inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. ENZON PHARMACEUTICALS, INC. By: /s/ Craig A. Tooman --------------------------------- Name: Craig A. Tooman Title: Executive Vice President, Finance and Chief Financial Officer Dated: July 6, 2006

EXHIBIT NO. DOCUMENT - ----------- -------- (a)(1)(A)* Offer to Purchase, dated June 6, 2006, as amended, June 23, 2006 (a)(1)(B)* Form of Letter of Transmittal (a)(1)(C)* Form of Letter to Brokers, Dealers, Commercial Banks, Trust Companies and Other Nominees (a)(1)(D)* Form of Letter to Clients for Use by Brokers, Dealers, Commercial Banks, Trust Companies and Other Nominees (a)(1)(E)* Press Release dated June 6, 2006 (a)(1)(F)+ Press Release dated July 6, 2006 (b) Not applicable (d)(1)* Indenture, dated as of June 26, 2001, between Enzon Pharmaceuticals, Inc. and Wilmington Trust Company, as trustee (filed as Exhibit 4.1 to the Enzon's Form S-3 (No. 333-67506) on August 14, 2001 and incorporated herein by reference) (d)(2)* Descriptions of Notes (filed as pages 17 through 26 of Enzon's Form S-3 (No.333-67506) on August 14, 2001 and incorporated herein by reference) (g) Not applicable (h) Not applicable - -------------------------------- + Filed herewith * Previously filed.




[Enzon Logo]                                               FOR IMMEDIATE RELEASE
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PRESS RELEASE                                   Contact: Craig Tooman
                                                         EVP, Finance and Chief
                                                         Financial Officer
                                                         908-541-8759

            ENZON PHARMACEUTICALS ANNOUNCES COMPLETION OF ITS TENDER
          OFFER FOR ITS 4 1/2% CONVERTIBLE SUBORDINATED NOTES DUE 2008

BRIDGEWATER,  NEW JERSEY,  JULY 6, 2006 - Enzon  Pharmaceuticals  Inc. ("Enzon")
announced  today the  completion  of its  tender  offer  for up to $180  million
aggregate principal amount of its 4 1/2% Convertible Subordinated Notes duE 2008
(the "Notes"), which expired Wednesday, July 5, 2006 at 5:00 p.m., New York City
time.  Enzon  received  valid  tenders  from holders of  $137,581,000  aggregate
principal   amount  and  accepted  all  tenders   validly  made.  As  of  today,
$122,642,000 aggregate principal amount of Notes remain outstanding.

The total consideration being paid to the holders of the Notes is $965.00 per
$1,000 principal amount of Notes accepted for purchase, plus accrued and unpaid
interest to, but excluding, the date of payment.

Goldman, Sachs & Co. acted as the dealer manager for the tender offer.
Wilmington Trust Company was the depositary, and D.F. King & Co., Inc. was the
information agent.

ABOUT ENZON

Enzon Pharmaceuticals, Inc. is a biopharmaceutical company dedicated to the
development and commercialization of therapeutics to treat patients with cancer
and adjacent diseases. Enzon's specialized sales force markets ABELCET(R),
ONCASPAR(R), ADAGEN(R), and DEPOCYT(R) in the United States. In addition, Enzon
also receives royaltiES on sales of PEG-INTRON(R), marketed by Schering-Plough
Corporation, and MACUGEN(R), marketed by OSI Pharmaceuticals aND Pfizer Inc.
Enzon's product-driven strategy includes an extensive drug development program
that leverages its proprietary technologies, including a Customized Linker
TechnologyTM PEGylation platform that utilizes customized linkers designed to
release compounds at a controlled rate. Enzon also utilizes contract
manufacturing opportunities to broaden its revenue base and enhance its
organizational productivity. Enzon complements its internal research and
development efforts with strategic initiatives, such as partnerships designed to
broaden its revenue base or provide access to promising new technologies or
product development opportunities. Further information about Enzon and this
press release can be found on the Company's Web site at www.enzon.com.