Prepared and filed by St Ives Burrups

Filed Pursuant to Rule 425
Under the Securities Act of 1933
And Deemed Filed Pursuant to Rule 14a-12
Under the Securities Exchange Act of 1934

Filed by Enzon Pharmaceuticals, Inc.
Subject Company: Enzon Pharmaceuticals, Inc.
NPS Pharmaceuticals, Inc.

Commission File No. 000-12957

The following materials were distributed by Enzon Pharmaceuticals, Inc. (“Enzon”) and NPS Pharmaceuticals, Inc. (“NPS”) to attendees of the SG Cowan 23rd Annual Healthcare Conference held on March 18, 2003 in Boston, Massachusetts to discuss the proposed business combination between Enzon and NPS.

 

 
 
 
 
 
Safe Harbor
Cautionary Statement For The Purpose Of The “Safe Harbor” Provisions Of The Private Securities Litigation Reform Act Of 1995
This presentation contains forward-looking statements within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995. These statements are based on management’s current expectations and beliefs and are subject to a number of factors and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements. The forward-looking statements contained in this presentation include statements about future financial and operating results and the proposed NPS/Enzon merger. These statements are not guarantees of future performance, involve certain risks, uncertainties and assumptions that are difficult to predict, and are based upon assumptions as to future events that may not prove accurate. Therefore, actual outcomes and results may differ materially from what is expressed herein. For example, if either of the companies do not receive required stockholder or governmental approvals or fail to satisfy other conditions to closing, the transaction will not be consummated. In any forward-looking statement in which NPS or Enzon expresses an expectation or belief as to future results, such expectation or belief is expressed in good faith and believed to have a reasonable basis, but there can be no assurance that the statement or expectation or belief will result or be achieved or accomplished. The following factors, among others, could cause actual results to differ materially from those described in the forward-looking statements: the risk that the NPS and Enzon businesses will not be integrated successfully; costs related to the proposed merger, failure of the NPS or Enzon stockholders to approve the proposed merger; and other economic, business, competitive and/or regulatory factors affecting NPS’ and Enzon’s businesses generally as set forth in NPS’s and Enzon’s filings with the SEC, including their Annual Reports on Form 10-K for their respective most recent fiscal years, especially in the Management’s Discussion and Analysis section, their most recent Quarterly Reports on Form 10-Q and their Current Reports on Form 8-K. NPS and Enzon are under no obligation to (and expressly disclaim any such obligation to) update or alter their forward-looking statements whether as a result of new information, future events or otherwise.
 
 
 
 
 
 

 
 
 
 
Safe Harbor continued
Additional Information And Where To Find It
In connection with the proposed NPS/Enzon merger, NPS, Enzon and Momentum Merger Corporation (which will be renamed by NPS and Enzon in connection with the proposed merger) intend to file a joint proxy statement/prospectus with the Securities and Exchange Commission (the “SEC”) in connection with the transaction described herein. INVESTORS AND SECURITY HOLDERS ARE URGED TO READ THE JOINT PROXY STATEMENT/PROSPECTUS WHEN IT BECOMES AVAILABLE BECAUSE IT WILL CONTAIN IMPORTANT INFORMATION ABOUT THE TRANSACTION DESCRIBED HEREIN. Investors and security holders may obtain a free copy of the joint proxy statement/prospectus (when it is available) and other documents filed by NPS and Enzon with the SEC at the SEC’s web site at www.sec.gov or by contacting NPS at 801-583-4939 and through NPS’s website at www.npsp.com or by contacting Enzon at 908-541-8678 and through Enzon’s website at www.enzon.com.
NPS and its directors and executive officers may be deemed to be participants in the solicitation of proxies from the stockholders of NPS and Enzon in connection with the transaction described herein. Information regarding the special interests of these directors and executive officers in the transaction described herein will be included in the joint proxy statement/prospectus described above.Additional information regarding these directors and executive officers is also included in NPS’ proxy statement for its 2002 Annual Meeting of Stockholders, which was filed with the SEC on or about April 19, 2002. This document isavailable free of charge at the SEC’s web site at www.sec.gov or by contacting NPS at 801-583-4939 and through NPS’ website at [www.npsp.com]
Enzon and its directors and executive officers also may be deemed to be participants in the solicitation of proxies from the stockholders of Enzon and NPS in connection with the transaction described herein. Information regarding the special interests of these directors and executive officers in the transaction described herein will be included in the joint proxy statement/prospectus described above. Additional information regarding these directors and executive officers is also included in Enzon’s proxy statement for its 2002 Annual Meeting of Stockholders, which was filed with the SEC on or about October 28, 2002. This document is available free of charge at the SEC’s web site at www.sec.gov or by contacting Enzon at 908-541-8678.
 
 
 
 
 
 

 
 
 
 
 
Our Mutual Goal
 
 
 
 
 
To Build a Sustainable Top-Tier Biotech Based On:
 
 
 
 
 
 
A deep, diversified and sustainable pipeline
 
 
 
 
 
 
A clearly defined pathway to profitability
 
 
 
 
 
 
A fully integrated infrastructure and stable financial position
 
 
 
 
 
 

 
A Fully Integrated Biotechnology Leader
 
 
Platform Technologies
 
Preclinical
 
Phase I
 
Phase II
 
Phase III
 
Commercialization & Manufacturing
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
                                     
 
PEGylation
 
SCA Projects
 
 
 
 
Prothecan
 
 
 
 
 
 
 
 
Single-Chain Antibodies
 
PEG-Cytoxics
 
 
 NPS 1776
 
   
 
 
 
 
PEG-INTRON
 
 
 
 
 
Inhaled Leuprolide
 
 
 
 
 
Cinacalcet
 
ABELCET
 
 
 
 
 
 
 
 
NPS 1506
 
 
 
 
   
 
ADAGEN
 
 
 
 
 
   
 
 
 Calcilytics
 
ALX-0600
 
PREOS
 
ONCASPAR
 
 
GPCR’s
 
Glycine Re-uptake Inhibitors
 
   
 
Cinacalcet
 
 
 
 
DEPOCYT
 
 
 
 
 
   
 
 
 
 
 
 
 
 
 
 
   
 
 
 
 
 
 
Metabotropic Glutamate Receptors
 
 
 
 
 
 
 
 
 
 
 
 
 
                                     
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
NPS
 
 
 
ENZON
 
 
 
 
 

 
 
 
 
 
Synergies Expand and Accelerate
Value Creation
 
 
 
 
 
 
 
 
Expand pipeline development
 
 
 
e.g., CNS product opportunities
 
 
 
 
 
Accelerate program development
 
 
 
e.g., ALX-0600 for multiple indications
 
 
 
 
 
Leverage financial strength and commercial capacity
 
 
 
e.g., in-license products and technologies, and optimize PREOS partnership
 
 
 
 
 
 
 
 
 
 
 

 
 
 
 
 
Transaction Specifics
 
 
 
 
 
Summary:
 
 
 

Stock for stock exchange

 
 
 
Timing
 
 
 
 
Joint proxy filed in March
 
 
 
 
Expected shareholder vote in June*
 
 
 
 
 
New Company Structure:
 
 
 
Hunter Jackson, Executive Chairman of the Board
 
 
 
Arthur Higgins, Chief Executive Officer
 
 
 
Board Split: 6 from NPS, 4 from Enzon
 
 
 
Management drawn from both companies
 
 
 
 
 
 
* Subject to stockholder and regulatory approvals and other customary closing conditions.
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
The New Entity
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 
 
 
 
 
The Merger Creates a Top-Tier Biotech
 
 
 
 
 
 
 
 
Management with a proven record of building businesses
 
 
 
 
 
 
Drug discovery and development expertise
 
 
 
 
 
 
Manufacturing capacity and experience
 
 
 
 
 
 
Commercial infrastructure
 
 
 
 
 
 
Strong, dependable revenues
 
 
 
 
 
 

 
 
 
 
 
 
Post Merger Strengths
 
 
 
 
 
 
 
 
Fully integrated:
 
 
 

From drug discovery through manufacturing and commercialization

 
 
 
 
 
Innovative and robust pipeline:
 
 
 
~$150M R&D budget *
 
 
 
Phase III: 2 programs
 
 
 
Phase II: 3 programs
 
 
 
>10 early stage programs
 
 
 
Multiple platform technologies
 
 
 
 
 
 
 
 
 
 
 
*Based upon 2003 pro-forma financials
 
 
 
 
 

 
 
 
 
 
Post Merger Strengths
 
 
 
 
 
 
 
 
Solid financial infrastructure:*
 
 
 

Revenue of ~$200M from 5 marketed products

 
 
 
>$300 million cash (at closing)
 
 
 
Solid cash flow
 
 
 
 
 
Significant partnerships validate R&D strengths:
 
 
 
 
 
 
Amgen
Janssen
MicroMet
 
 
 
 
 
 
AstraZeneca
Kirin
Nektar
 
 
 
 
 
 
GSK
Schering-Plough
SkyePharma
 
 
 
 
 
 
 
 
 
 
 
* Based upon 2003 pro-forma financials
 
 
 
 
 

 
 
Post-Merger Metrics
 
 
 
 
Comparable Company Analysis(a)
 
 
 
 
 
 
 
2003 Est.
 
 
Products
 
 
 
 
 
 
 
 

 
 
 
 
 
 
Company
 
 
Market Value
 
Revenue
 
 
R&D
 
 
Marketed
 
 
Phase III
 
 

 
Millennium
 
$
2,152.2
 
$
402.5
 
$
496.5
 
 
2
 
 
 
 
 
Celgene
 
$
1,942.9
 
$
171.0
 
$
89.8
 
 
1
 
 
1
 
 
 
Amylin
 
$
1,334.2
 
$
49.4
 
$
111.8
 
 
0
 
 
1
 
 
 
Neurocrine
 
$
1,297.1
 
$
92.0
 
$
110.5
 
 
0
 
 
1
 
 
 
ICOS
 
$
1,055.7
 
$
105.5
 
$
157.5
 
 
0
 
 
1
 
 

 
Enzon/NPS
 
 
 
 
$
~200.0
 
$
>150.0
 
 
5
 
 
2
 
 

 
(a) Projected Financial Information as per Wall Street equity research and calendarized to reflect 12/31 year end
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Pipeline, Products
& Technologies
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 
 
Product Pipeline & Marketed Products
 
 
 
 
 
Product
Preclinical/
Research
Phase I
Phase II
Phase III
Marketed
 
Partner
 
PEG-INTRON
 
Schering-Plough
 
ABELCET
 
Proprietary
 
ADAGEN
 
Proprietary
 
ONCASPAR
 
Proprietary
 
DEPOCYT
 
Proprietary
 
CinacalcetHCl
 
 
Amgen/Kirin
 
PREOS
 
 
Proprietary
 
PROTHECAN
 
 
 
Proprietary
 
ALX-0600
 
 
 
Proprietary
 
CinacalcetHCl
 
 
 
Amgen/Kirin
 
NPS 1776
 
 
 
 
Proprietary
 
NPS 1506
 
 
 
 
Proprietary
 
Calcilytics
 
 
 
 
GSK
 
PEG-Cytotoxics
 
 
 
 
 
Proprietary
 
Gly-T Inhibitors
 
 
 
 
 
Janssen
 
mGluRs
 
 
 
 
 
AstraZeneca
 
SCA’s
 
 
 
 
 
Micromet
 
Inhaled Leuprolide
 
 
 
 
 
Nektar
 
 
 
= Enzon
= NPS
 
 
 

 
 
 
 
 
5 Marketed Products
 
 
 
 
 
 
 
 
 
 
 
 
 
PEG-INTRON®
 
 
 
 
 
 
ABELCET®
 
 
 
 
 
 
ONCASPAR®
 
 
 
 
 
 
DEPOCYT®
 
 
 
 
 
 
ADAGEN®
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 
 
 
 
 
PEG-INTRON
 
 
 
 
 
HCV--an under-treated epidemic
 
 
 
Est. 4 Million U.S./4 Million EU
 
 
 
 
 
Re-treatment patients
 
 
 
~200,000 patients
 
 
 
 
 
Maintenance therapy
 
 
 
CO-PILOT study ongoing
 
 
 
 
 
Geographic & indication expansion
 
 
 
Japan - Est. 2 million infected
 
 
 
Oncology/HIV
 
 
 
 
 
 
 
 
 
 

 
 
 
 
 
PEG-INTRON:
A Strong Revenue Base
 
 
 
 
 
 
 
 
U.S. Pegylated alpha-interferon scripts increasing
 
 
 
 
 
 
Roche share of new U.S. scripts holding at approximately 20%
 
 
 
 
 
 
Japan represents significant upside beginning in 2005
 
 
 
 
 
 
Solid intellectual property position
 
 
 
 
 
 
Potential for price increases and expanded indications
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
ABELCET is the market leader and formulation of choice
 
 
 
 
 
Amphotericin B lipid complex with reduced nephrotoxicity
 
 
 
 
 
Possible market expansion through:
 
 
 
Focused marketing and medical effort
 
 
 
Evaluation of new treatment paradigms
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 
 
 
 
 
Additional Marketed Products
 
 
 
 
 
 
 
 
ONCASPAR (pegylated asparaginase)
 
 
 
Indicated for acute lymphoblastic leukemia
 
 
 
Stable sales growth
 
 
 
 
 
DEPOCYT (cytarabine liposome injection)
 
 
 
Treatment of neoplastic meningitis
 
 
 
Significant growth potential
 
 
 
 
 
ADAGEN  (pegylated bovine ADA)
 
 
 
ADA deficient SCIDS (Bubble Boy Disease)
 
 
 
Lifetime therapy for limited population
 
 
 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
2 Phase III Clinical Products
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
PREOS™
 
Cinacalcet HCl
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
PREOS™
(Intact Human Parathyroid Hormone)
 
 
 
 
 
 
 
 
Stimulates natural bone growth, with potential for:
 
 
 
 
Stronger, healthier bones
 
 
 
 
A lower risk of fracture
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Recent PaTH data support Phase II results and possible PREOS and bisphosphonate combination
 
 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
PREOS™
 
 
 
 
 
 
Expect to compete in a large and growing market
 
 
 
 
 
 
Pivotal Phase III study to be completed in September 2003
 
 
 
 
 
 
FDA submission targeted for mid-2004
 
 
 
 
 
 
Launch anticipated by late 2005
 
 
 
 
 
 
Combined company more able to aggressively execute development program and negotiate an optimal partnership
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 
 
 
 
 
Cinacalcet HCl
 
 
 
 
 
 
 
 
Novel treatment for hyperparathyroidism (HPT)
 
 
 
 
 
 
 
 
Market opportunity (U.S.)
 
 
 
 
Primary HPT 500,000 patients
 
 
 
 
Secondary HPT 280,000 dialysis patients
 
 
 
 
Secondary HPT 800,000 predialysis patients
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 
 
 
 
 
Cinacalcet HCl
 
 
 
 
 
 
Amgen’s Phase III program on-going and on-track
 
 
 
 
 
 
Amgen confirms 2H 03 NDA filing
 
 
 
 
 
 
First-in-class molecule in a growing market
 
 
 
 
 
 
Potential for significant royalty stream
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 
 
Product Pipeline & Marketed Products
 
 
 
 
 
Product
Preclinical/
Research
Phase I
Phase II
Phase III
Marketed
 
Partner
 
PEG-INTRON
 
Schering-Plough
 
ABELCET
 
Proprietary
 
ADAGEN
 
Proprietary
 
ONCASPAR
 
Proprietary
 
DEPOCYT
 
Proprietary
 
CinacalcetHCl
 
 
Amgen/Kirin
 
PREOS
 
 
Proprietary
 
PROTHECAN
 
 
 
Proprietary
 
ALX-0600
 
 
 
Proprietary
 
CinacalcetHCl
 
 
 
Amgen/Kirin
 
NPS 1776
 
 
 
 
Proprietary
 
NPS 1506
 
 
 
 
Proprietary
 
Calcilytics
 
 
 
 
GSK
 
PEG-Cytotoxics
 
 
 
 
 
Proprietary
 
Gly-T Inhibitors
 
 
 
 
 
Janssen
 
mGluRs
 
 
 
 
 
AstraZeneca
 
SCA’s
 
 
 
 
 
Micromet
 
Inhaled Leuprolide
 
 
 
 
 
Nektar
 
 
 
= Enzon
= NPS
 
 
 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Operational Overview
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 
 
 
 
Combined Management Team Includes:
 
 
 
 
Hunter Jackson, Ph.D. (NPS)
 
 
Executive Chairman of the Board
 
 
 
 
Arthur J. Higgins (Enzon)
 
 
Chief Executive Officer
 
 
 
 
Ulrich Grau, Ph.D. (Enzon)
 
 
Chief Scientific Officer
 
 
 
 
Kenneth J. Zuerblis (Enzon)
 
 
Vice President, Finance, Chief Financial Officer & Secretary
 
 
 
 
Thomas B. Marriott, Ph.D. (NPS)
 
 
Vice President Development Research
 
 
 
 
Alan Mueller, Ph.D. (NPS)
 
 
Vice President Discovery Research
 
 
 
 
 
 
 

 
 
Locations
 

 
 
Selected Pro-Forma Financials
 
 
 
 
 
Pro-Forma Operating Summary
(US$ in millions)
 
 
Year Ending December 31,2002
Pro Forma 2002
 
 
 
 
 
 
 
 
Product Revenues:
 
 
 
 
 
Sales
$
31.5
 
 
 
Royalties
$
82.6
 
 
 
 
$
114.1
*
 
 
*(Current estimated annualized revenues = $200.0)
 
 
 
 
 
 
 
 
 
 
 
Expenses:
 
 
 
 
 
SG&A
$
48.0
 
 
 
R&D
$
102.0
 
 
 
 
 
 
 
 
 
Long-Term Convertible Debt
$
400.0
 
 
 
 
 
 
 
 
 
Ending Cash Balance
$
380.0
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 
 
 
 
Expected Milestones and News Flow
 
             
 
Type
           
2003              
2004      
     
 
 
 
 
 
 
 
Clinical Data
Phase III CinacalcetHCl data in secondary HPT
 
Regulatory
File CinacalcetHClNDA
 
Clinical Data
PREOS 2-year rat toxicology study data
 
Clinical Data
PREOS TOP Study completed
 
Clinical Data
Phase IIa results from PROTHECAN
 
Clinical Data
Initiate additional PII/III ALX-0600 (SBS)
 
Market Data
HCV maintenance studies
 
Regulatory
File PREOS NDA
 
Regulatory
ProthecanPhase III program
 
Clinical Data
CinacalcetHCl approval
     
 
 
 = NPS
 
 = Enzon
 
 
 
 
 
 
 
 
 

 
 
 
 
 
Synergies Expand and Accelerate
Value Creation
 
 
 
 
 
 
 
 
Expand pipeline development
 
 
 
e.g., CNS product opportunities
 
 
 
 
 
Accelerate program development
 
 
 
e.g., ALX-0600 for multiple indications
 
 
 
 
 
Leverage financial strength and commercial capacity
 
 
 
e.g., in-license products and technologies, and optimize PREOS partnership
 
 
 
 
 
 
 
 
 
 
 

 
 
2007... Where We’re Going
 
 
 
 
 
Revenue > $500M
 
 
 
 
 
 
Strong, balanced clinical pipeline
 
 
 
 
 
 
R&D budget > $180M
 
 
 
 
 
 
EBITDA > $100M
 
 
 
 
 
 
Industry leading growth rate
 
 
 
 
 
 
Cash > $500M