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OMB APPROVAL
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OMB Number  3295-0287
Expires: September 30, 1998
Estimated average burden
hours per response ....... 0.5
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

FORM 4

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,
Section 17(a) of the Public Utility Holding Company Act of 1935 or
Section 30(f) of the Investment Company Act of 1940

[  ] Check this box if no longer subject to Section 16. Form 4 or Form 5
obligations may continue. See Instruction 1(b).

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1. Name and Address of Reporting Person*

Zuerblis                            Kenneth                 J.
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(Last)                           (First)             (Middle)

C/O  Enzon, Inc.             20 Kingsbridge Road
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(Street)

Piscataway                            NJ                 08854
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(City)                           (State)              (Zip)

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2. Issuer Name and Ticker or Trading Symbol

Enzon, Inc. (ENZN)
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3. IRS or Social Security Number of Reporting Person (Voluntary)

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4. Statement for Month/Year

December 1997
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5. If Amendment, Date of Original (Month/Year)

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6. Relationship of Reporting Person to Issuer
(Check all applicable)

[   ]   Director                             [   ]   10% Owner
[ X ]   Officer (give title below)           [   ]   Other (specify below)

Vice President, Finance and Chief Financial Officer

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7. Individual or Joint/Group Filing (Check applicable line)

[ X ] Form filed by One Reporting Person
[   ] Form filed by More than One Reporting Person

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Table I -- Non-Derivative Securities Acquired, Disposed of,
or Beneficially Owned
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6.
4.                              5.             Owner-
Securities Acquired (A) or      Amount of      ship
3.           Disposed of (D)                 Securities     Form:     7.
Transaction  (Instr. 3, 4 and 5)             Beneficially   Direct    Nature of
2.            Code         ------------------------------- Owned at End   (D) or    Indirect
1.                                    Transaction   (Instr. 8)                   (A)             of Month       Indirect  Beneficial
Title of Security                     Date          ------------     Amount      or     Price    (Instr. 3      (I)       Ownership
(Instr. 3)                            (mm/dd/yy)     Code     V                  (D)             and 4)         (Instr.4) (Instr. 4)
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Common Stock                           12/4/97       S                5,000      D      $6.125
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Common Stock                           12/4/97       S                5,000      D      $6.000
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Common Stock                           12/5/97       S               20,000      D      $6.000
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Common Stock                           12/4/97       M               10,000      A      $2.094
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Common Stock                           12/5/97       M               20,000      A      $2.094      1,600        D
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Reminder: Report on a separate line for each class of securities beneficially
owned directly or indirectly.

* If the Form is filed by more than one Reporting Person, see Instruction 
4(b)(v).

Page 1 of 2

FORM 4 (continued)

Table II -- Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

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9.        10.    
Number    Owner- 
of        ship   
2.                                                                                    Deriv-    of     
Conver-                    5.                              7.                         ative     Deriv-   11.    
sion                       Number of                       Title and Amount           Secur-    ative    Nature 
of                         Derivative    6.                of Underlying     8.       ities     Secur-   of     
Exer-             4.       Securities    Date              Securities        Price    Bene-     ity:     In-    
cise     3.       Trans-   Acquired (A)  Exercisable and   (Instr. 3 and 4)  of       ficially  Direct   direct 
Price    Trans-   action   or Disposed   Expiration Date   ----------------  Deriv-   Owned     (D) or   Bene-  
1.                  of       action   Code     of(D)         (Month/Day/Year)            Amount  ative    at End    In-      ficial 
Title of            Deriv-   Date     (Instr.  (Instr. 3,    ----------------            or      Secur-   of        direct   Owner- 
Derivative          ative    (Month/  8)       4 and 5)      Date     Expira-            Number  ity      Month     (I)      ship   
Security            Secur-   Day/     ------   ------------  Exer-    tion               of      (Instr.  (Instr.   (Instr.  (Instr.
(Instr. 3)          ity      Year)    Code V    (A)  (D)     cisable  Date     Title     Shares  5)       4)        4)       4)
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Stock Option        $2.094   12/4/97  M              10,000  1/20/96  1/20/05   Common   10,000   -        -        D
(right to buy)                                                                  Stock 
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Stock Option        $2.094   12/4/97  M              20,000  1/20/96  1/20/05   Common   20,000   -        -        D
(right to buy)                                                                  Stock
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Explanation of Responses:

/s/ Kenneth J. Zuerblis                                        01/08/98
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**Signature of Reporting Person                             Date

**     Intentional misstatements or omissions of facts constitute Federal 
Criminal Violations.

See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note:  File three copies of this Form, one of which must be manually signed.
If space provided is insufficient, see Instruction 6 for procedures.

Potential persons who are to respond to the collection of information contained
in this form are not required to respond unless the form displays a currently
valid OMB Number.

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