The first oral presentation, titled "PEG-based Prodrugs Improve the Anticancer Activity of Small Molecule Cytotoxics," will be given by
Dr. Zhao's presentation will cover the use of Enzon's innovative, releasable Customized Linker Technology® as a means of improving the therapeutic activity of approved small molecule cytotoxic agents. The presentation will include data demonstrating the ability of Enzon's releasable PEG linkers to increase solubility, provide extended exposure of the released cytotoxic, reduce unwanted toxicities, improve tumor accumulation of the cytotoxic agent and, most remarkably, dramatically enhance antitumor activity in animal models compared to non-PEGylated agents. Dr. Zhao will also highlight the use of PEGylation with anti-cancer agents in the clinic, including the Enzon-developed molecule PEG-SN38, which is currently undergoing clinical evaluation in patients with advanced colorectal, breast, or pediatric cancers. Development and commercialization rights to PEG-SN38 in
The second oral presentation, titled "The Proven Therapeutic Utility of Permanent and Releasable PEGylation Linkers," will be given by
Dr. Conover will present an overview of Enzon's innovative, permanent and releasable Customized Linker Technology® in commercial, clinical and research applications across disease areas and therapeutic classes. Enzon has developed the industry leading PEGylation technologies utilizing both permanent and releasable Customized Linker Technology®. To date, the Company's technology and know-how have been used to develop eight marketed products with combined annual sales of over
Companies interested in partnership opportunities to gain access to Enzon's PEGylation technology can contact Enzon at firstname.lastname@example.org
About Enzon's Customized Linker Technology®
PEGylation has successfully been used on various pharmaceutical compounds, including enzymes, peptides and antibodies, to improve their pharmaceutical properties through the chemical attachment of polyethylene glycol (PEG) using our Customized Linker Technology. PEGylation technology employs proprietary chemical linkers designed to either release the native molecule at a controlled rate or provide permanent linkage that will maximize inherent activity of the parent molecule. In some cases, PEGylation can render a compound therapeutically effective, whereas the unmodified form had only limited clinical utility.
This press release contains, or may contain, forward-looking statements within the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release, other than statements that are purely historical, are forward-looking statements, which can be identified by the use of forward-looking terminology such as the words "believes," "expects," "may," "will," "should," "potential," "anticipates," "plans," or "intends" and similar expressions.
Such forward-looking statements are based upon management's present expectations, objectives, anticipation, plans, hopes, beliefs, intentions or strategies regarding the future and are subject to known and unknown risks and uncertainties that could cause actual results, events or developments to be materially different from those indicated in such forward-looking statements. The results of preclinical data are not necessarily indicative of clinical efficacy. A more detailed discussion of these and other factors that could affect results is contained in Enzon's filings with the
Andrea Rabney Argot Partners212.600.1902 Email Contact Media Contact: Eliza Schleifstein Argot Partners212.600.1902 Email Contact
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